Cardiovascular Drugs

1.

Which of the following statements most closely describes the current status of angiotensin converting enzyme inhibitors in congestive heart failure-

They are used when diuretics alone fail

They are to be used as adjuncts only in resistant cases

They are the first choice drugs unless contraindicated

They are a substitute for digitalis

2.

Digitalis slows the heart in congestive heart failure by-

All of the above

Direct depression of sinoatrial node

Increasing vagal tone

Decreasing sympathetic overactivity

3.

The following angiotensin converting enzyme inhibitor can reduce cardiac contractility-

Perindopril

Captopril

Enalapril

Lisinopril

4.

Potentiation of bradykinin appears to play a role in the following effects of angiotensin converting enzyme inhibitors except-

Angioedema in susceptible individuals

Fall in BP in the long term

Fall in BP in the short term

Cough in susceptible individuals

5.

The following drug increases cardiac output in congestive heart failure without having any direct myocardial action-

Dobutamine

Amrinone

Digoxin

Captopril

6.

Captopril produces greater fall in blood pressure in-

Diuretic treated patients

Untreated CHF patients

Patients having low plasma renin activity

Sodium replete normotensive individuals

7.

An elderly hypertensive was treated with hydrochlorothiazide 50 mg daily. Even after a month, his BP was not reduced to the desired level and another antihypertensive was added. After 2 hours of taking the other drug his BP fell precipitously. The most likely other drug given to him is-

Amlodipine

Methyldopa

Captopril

Atenolol

8.

Losartan differs from enalapril in the following respect-

It impairs carbohydrate tolerance

It depresses cardiovascular reflexes

It does not potentiate bradykinin

It does not have fetopathic potential

9.

Angiotensin II causes rise in blood pressure by-